Optopharma Ltd. specializes in improved inhibitors for research. Our first products are myosin 2 inhibitors:

Non-phototoxic, stable and non-cytotoxic myosin inhibitor, para-nitroblebbistatin

nitrobleb

Reference: Para-nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor by M. Képiró, B. H. Várkuti, L. Végner, G. Vörös, Gy. Hegyi, M. Varga, A. Málnási-Csizmadia in Angewandte Chemie Volume 53, Issue 31, July 28, 2014, DOI: 10.1002/anie.201403540 Pubmed link

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For data sheet and recommendations for usage click here.

Para-nitroblebbistatin has already been used in independent research articles:

  • Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly by T. Soykan et al in Neuron 93, February 22, 2017, DOI:10.1016/j.neuron.2017.02.011 Link
  • Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells by M. Chabaud et al in Nature Communications 6, June 25, 2015, DOI:10.1038/ncomms8526 Link
  • Formin-generated actomyosin arcs proper T cell receptor microcluster movement at the immune synapse by S. Murugesan et al in J. Cell Biol. October 31, 2016, DOI: 10.1083/jcb.201603080 Link
  • The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes by Osteikoetxea-Molnar et al in Cell. Mol. Life Sci. April 28, 2016 DOI 10.1007/s00018-016-2233-y Link
  • Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation by Letelier et al in PNAS April 2, 2018 DOI 10.1073/pnas.1719885115 Link
  • Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments by Spira et al in eLife November 6, 2017 DOI 10.7554/eLife.30867 Link

Highly soluble derivative, para-aminoblebbistatin

amino-patented-structure.pngReference: A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative by Boglárka H. Várkuti; Miklós Képiró;  Ádám I. Horváth; László Végner; Szilvia Ráti; Áron Zsigmond; György Hegyi; Zsolt Lenkei; Máté Varga  in  Scientific Reports. 6: 26141. 2016 May 31 doi:10.1038/srep26141 PubMed Link

Para-aminoblebbistatin has been suggested as one of the best compounds to replace blebbistatin in a review by Roman et al.

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For data sheet and recommendations for usage click here.

Photoreactive myosin inhibitor, azidoblebbistatin

azidobleb

Reference: Azidoblebbistatin, a photoreactive myosin inhibitor by Miklós Képiró, Boglárka H. Várkuti, Andrea Bodor, György Hegyi, László Drahos, Mihály Kovács, András Málnási-Csizmadia in Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9402-7. doi: 10.1073/pnas.1202786109 Pubmed link

In vivo application reference: Molecular tattoo: subcellular confinement of drug effects by Képiró M, Várkuti BH, Rauscher AA, Kellermayer MS, Varga M, Málnási-Csizmadia A. in Chem Biol. 2015 Apr 23;22(4):548-58. doi: 10.1016/j.chembiol.2015.03.013 Pubmed link

REQUEST QUOTE FOR THIS COMPOUND

For data sheet and recommendations for usage click here.

Quote request and ordering information

We ship worldwide and accept both bank transfer and credit cards. Please send us a message for requests to rita.bezegh@optopharma.com

Alternatively, you can contact us using the form below.

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