Optopharma Ltd. specializes in improved inhibitors for research. Our first products are modified blebbistatin inhibitors:

Non-phototoxic, stable and non-cytotoxic myosin inhibitor, para-nitroblebbistatin

nitrobleb

Reference: Para-nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor by M. Képiró, B. H. Várkuti, L. Végner, G. Vörös, Gy. Hegyi, M. Varga, A. Málnási-Csizmadia in Angewandte Chemie Volume 53, Issue 31, July 28, 2014, DOI: 10.1002/anie.201403540 Pubmed link

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This compound was used in 3 independent research articles:

  • Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells by M. Chabaud et al in Nature Communications 6, June 25, 2015, DOI:10.1038/ncomms8526 Link
  • Formin-generated actomyosin arcs proper T cell receptor microcluster movement at the immune synapse by S. Murugesan et al in J. Cell Biol. October 31, 2016, DOI: 10.1083/jcb.201603080 Link
  • The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes by Osteikoetxea-Molnar et al in Cell. Mol. Life Sci. April 28, 2016 DOI 10.1007/s00018-016-2233-y Link

 

Photoreactive myosin inhibitor, azidoblebbistatin

azidobleb

Reference: Azidoblebbistatin, a photoreactive myosin inhibitor by Miklós Képiró, Boglárka H. Várkuti, Andrea Bodor, György Hegyi, László Drahos, Mihály Kovács, András Málnási-Csizmadia in Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9402-7. doi: 10.1073/pnas.1202786109 Pubmed link

In vivo application reference: Molecular tattoo: subcellular confinement of drug effects by Képiró M, Várkuti BH, Rauscher AA, Kellermayer MS, Varga M, Málnási-Csizmadia A. in Chem Biol. 2015 Apr 23;22(4):548-58. doi: 10.1016/j.chembiol.2015.03.013 Pubmed link

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